Type 2 diabetes therapy
Targeted detection and treatment: personalized diagnostics for sustainable therapy
Introduction
Prof. Dr. Dr. Pfützner’s personalized diabetes therapy aims to treat type 2 diabetes in a new, scientifically sound way.
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The approach is based on 30 years of in-house research and relies on customized treatment that goes beyond the usual sugar control and focuses on the complex disease process. Using a targeted combination of modern medication, specific lifestyle advice and the innovative analysis of individual biomarkers, the therapy is tailored to the specific needs of each patient.
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Diabetes is inherited through so-called dominant genes. If you carry these genes, you will develop the disorder sooner or later. You can actually influence the time of manifestation by your lifestyle. But your risk is 50 percent if one parent has diabetes and even 75 percent if both parents are affected.
Who is this therapy suitable for?
This therapy is aimed at people with type 2 diabetes who do not achieve the desired results with conventional methods, as well as people who want a more comprehensive, cause-oriented treatment.
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Patients whose family history shows an increased risk of diabetes or who suffer from other diseases such as high blood pressure or lipometabolic disorders in addition to diabetes also benefit from this personalized therapy. The therapy approach also makes sense for those who want to start treatment early in order to prevent long-term damage such as neuropathy or kidney damage.
What does the therapy do?
Personalized diabetes therapy aims to treat type 2 diabetes fundamentally and in the long term, rather than just alleviating the symptoms.
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It is based on comprehensive diagnostics that go far beyond the usual blood glucose and HbA1c levels. Through targeted phenotyping and the use of specific biomarkers, an individual disease profile is created that sheds light on the exact cause of the diabetes.
In concrete terms, the therapy does the following:
Targeted treatment of causes:
Based on the diagnosed basic disorders – such as insulin resistance, excessive visceral adipose tissue and beta-cell dysfunction – the therapy is designed to directly address the basic disorders.
Long-term stabilization of blood sugar:
Treatment aims to stabilize blood glucose levels over the long term and control the disease, which can halt the deterioration of diabetes.
Prevention of late damage:
Early and targeted therapy can prevent or delay common late effects such as cardiovascular disease, kidney damage and nerve problems (neuropathy).
Minimization of drug dependency:
Tailored use of medication that is optimally adapted to the individual phenotype helps to avoid unnecessary medication and prevent long-term side effects.
Improving quality of life:
By directly influencing the disease and avoiding complications and side effects, therapy offers patients the chance of a more active and healthier life.
This holistic and precise approach offers people an alternative to conventional therapy and is aimed in particular at those who want to control their diabetes not just symptomatically, but fundamentally and in the long term.
Which side effects may occur?
Personalized diabetes therapy is designed to respond to the individual’s needs and to optimize treatment as specifically as possible.
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All medications used are approved for the treatment of diabetes mellitus.However, as the therapy varies depending on the specific phenotype and the measures used, various side effects can occur.
The frequency and severity of these side effects depend on the type of therapy (medication, diet, lifestyle) and the individual reaction of the patient.
Possible side effects include:
Drug-related side effects:
Metformin (commonly used for type 2 diabetes):
Possible side effects may include gastrointestinal symptoms such as nausea, diarrhea or abdominal pain. In rare cases, lactic acidosis may occur, which is a serious but rare complication.
GLP-1 receptor agonists:
These drugs can cause gastrointestinal symptoms such as nausea and vomiting. In rare cases, inflammation of the pancreas (pancreatitis) may occur.
SGLT-2 inhibitors:
Possible side effects include increased urination, urinary tract infections and, in rare cases, ketoacidosis, a serious metabolic disorder.
Hypoglycemia (low blood sugar):
When using insulin or certain oral antidiabetic drugs, there is a risk that the blood sugar drops too low, which can lead to hypoglycemia. Symptoms include trembling, sweating, dizziness and, in the worst case, loss of consciousness.
Changes in weight progression:
Some patients may experience unwanted weight gain or loss, depending on the type of therapy (e.g. medication, dietary changes).
Changes in blood pressure:
Some medications, such as SGLT-2 inhibitors, can lead to a drop in blood pressure, which may cause dizziness or circulatory problems in some patients.
Malnutrition or dehydration:
Malnutrition can occur with extreme dietary changes (e.g. very low carbohydrate intake or ketogenic diet), especially if there is insufficient nutrient intake.
Increased excretion of fluid due to medications such as SGLT-2 inhibitors could lead to dehydration.
Psychological stress:
Lifestyle changes and more intense management of the disease can cause stress or psychological distress in some patients.
Long-term effects of medication:
Some medications, especially those used to regulate insulin levels, could have potential side effects on the cardiovascular or renal systems with long-term use.
It is important to emphasize that not every patient will experience these side effects. Therapy is individualized to the patient, and regular monitoring helps to identify potential side effects early and adjust treatment if necessary.
Patients should stay in regular contact with their treating physician or therapist to monitor therapy, discuss any side effects and make adjustments.
How does the therapy work?
The first step in therapy is a comprehensive examination and phenotyping, which is individually tailored to the patient.
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Genetic predispositions and specific biomarkers are examined in order to determine the exact clinical picture. On this basis, Professor Pfützner’s team creates a personalized treatment strategy that includes the following elements:
Lifestyle counseling:
To lower the hormonal activity of adipose tissue and reduce insulin resistance, an emphasis is placed on a low-carbohydrate diet and moderate-intensity exercise.
Drug therapy:
Therapy is designed to address various underlying disorders, such as insulin resistance, beta-cell dysfunction and hormonal imbalances. Drugs such as GLP-1 analogs and SGLT-2 inhibitors are often used to slow down weight gain and promote metabolic balance.
Targeted insulin administration (if appropriate):
In many cases, insulin is given in low doses to minimize stress on beta cells and ensure stable blood glucose levels.
The therapy is continued for at least three months and regularly checked for its effect.
The aim is to stabilize the course of the disease and ensure long-term metabolic control.
Do I have to come to Mainz for this?
For personalized diabetes therapy, it makes sense to visit the private practice in Mainz at least at the start of treatment and for specific examinations if necessary. In Switzerland, we work with the Swiss Mountain Clinic in Castaneda (www.swissmountainclinic.com) for SOC+.
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Comprehensive diagnostics, including phenotyping and biomarker-based analyses, are carried out on site in order to adapt the therapy to the individual type of diabetes and specific needs. These diagnoses form the basis for a customized treatment plan.
The actual treatment and care can often also be decentralized, for example through regular coordination with the medical team and possible continuation in cooperation with the family doctor. This ensures that both the precise diagnostics and specialist knowledge of the institute as well as continuous local care can be optimally utilized.
What is the difference to conventional therapy?
In contrast to traditional diabetes treatment, which concentrates primarily on lowering blood sugar levels, the Pfützner Science & Health Institute’s therapy focuses on holistic treatment of the basic metabolic disorders.
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While conventional therapy often involves standardized procedures with an escalation from lifestyle changes to tablets and insulin therapy, our treatment is individually adapted:
Phenotypic and genetic analysis:
Therapy is based on a detailed analysis of the individual clinical picture, which enables a targeted selection of therapeutic measures.
Early use of insulin:
While insulin is often used as a last resort in conventional therapy, at our institute, targeted insulin is administered to support the beta cells where appropriate to prevent disease progression.
Comprehensive risk minimization:
In addition to blood glucose control, specific attention is paid to reducing the risk of atherosclerosis and avoiding late damage, which leads to an overall better long-term prognosis.
Conclusion on personalized type 2 diabetes treatment
The personalized diabetes therapy of Pfützner Science & Health Institute is a comprehensive alternative to conventional blood glucose-focused treatment of type 2 diabetes. It specifically addresses the complex metabolic disorders and enables individualized, early treatment that can prevent the progression of the disease and ensure quality of life in the long term. The unique combination of scientific diagnostics and tailored therapy offers patients the chance of more stable and effective diabetes control.
Videos on personalized diabetes therapy / SOC +
Case study from our practice
Newly manifested diabetes
Therapy adjustment after side effects
Case study SOC+
The 62-year-old female patient VLT was first presented by her GP in 2010 with an HbA1c of 10.2%.
With a height of 175 cm and a weight of 94 kg, she had a BMI of 30.7 kg/m². The initial therapy with metformin 500 mg led to gastrointestinal side effects, so treatment was switched to glimepiride 3 mg.
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